What is L-Leucine?

L-Leucine, one of the three amino acids referred to as branched-chain amino acids found in the dietary sources including brown rice, beans, meat, nuts, whole wheat and soy flour. It is involved in muscle synthesis, as well as protecting muscles and helping to promote the healing of muscle tissue as well as bone and skin tissue. It may help lower elevated blood sugar levels, and is involved in increasing hormone production. Low levels have been noted in those with chronic wasting diseases and chronic fatigue syndrome. L-Leucine, along with the other branched -chain amino acids are recommended to help promote healling in surgical patients.

Who needs it and what are some symptoms of deficiency?

L-Leucine is an essential amino acid. Therefore, everyone needs L-Leucine to maintain basic health. Deficiency of L-Leucine is rare. Insulin deficiency is known to result in poor utilization of leucine. A deficiency of leucine can cause a biochemical malfunction producing hypoglycemia in infants.

How much should be taken? Are there side effects?

Supplemental L-Leucine should always be taken with a correct balance of the other two branched-chain amino acids, L-Isoleucine and L-valine: approximately 2 milligrams of L-Leucine for each 1 milligram of L-Valine and L-Isoleucine. A nutritional conflict might occur with L-Isoleucine and L-Valine if they are not taken in a well-balanced portion (1-to-1). L-Leucine is considered safe for general use. People with depression, liver or kidney disease should avoid taking large amounts of leucine due to the changes of blood levels. L-Leucine may interfere with L-dopa, however, a medication used to control the symptoms of Parkinson's disease and should be used only under medical supervision in these patients.